Drug interactions
Glecaprevir / pibrentasvir + Mitomycin
Severity: Minor
Glecaprevir / pibrentasvir and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase exposure to P-gp substrates. The effect on mitomycin has not been well characterized and is probably small with intermittent mitomycin dosing.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by glecaprevir and pibrentasvir.
What to do
Monitor blood counts and mitomycin-related toxicity during concurrent use. Reduce the mitomycin dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Mitomycin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase exposure to P-gp substrates. The effect on mitomycin has not been well characterized and is probably small with intermittent mitomycin dosing.
How serious is the interaction between Glecaprevir / pibrentasvir and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and mitomycin-related toxicity during concurrent use. Reduce the mitomycin dose if toxicity develops.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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