Drug interactions
Glecaprevir / pibrentasvir + Rolapitant
Severity: Moderate
Glecaprevir / pibrentasvir and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits intestinal P-gp and BCRP, which can raise exposure to glecaprevir and pibrentasvir, both of which are substrates of these transporters. The effect is probably modest and most relevant after a single oral antiemetic dose.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-gp and BCRP efflux transport by rolapitant increases absorption of glecaprevir and pibrentasvir.
What to do
Co-administration is acceptable with monitoring for adverse effects such as headache, nausea and liver enzyme elevation. No empiric dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Rolapitant?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits intestinal P-gp and BCRP, which can raise exposure to glecaprevir and pibrentasvir, both of which are substrates of these transporters. The effect is probably modest and most relevant after a single oral antiemetic dose.
How serious is the interaction between Glecaprevir / pibrentasvir and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administration is acceptable with monitoring for adverse effects such as headache, nausea and liver enzyme elevation. No empiric dose change is needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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