Drug interactions
Glecaprevir / pibrentasvir + Silodosin
Severity: Moderate
Glecaprevir / pibrentasvir and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, and silodosin is a P-gp substrate. Silodosin exposure may rise, increasing orthostatic hypotension, dizziness and other adverse effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal and cellular P-glycoprotein efflux increases silodosin absorption and exposure.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting the antiviral regimen. Counsel the patient to rise slowly and consider silodosin dose review if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Silodosin?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein, and silodosin is a P-gp substrate. Silodosin exposure may rise, increasing orthostatic hypotension, dizziness and other adverse effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting the antiviral regimen. Counsel the patient to rise slowly and consider silodosin dose review if symptoms occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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