Drug interactions
Glecaprevir / pibrentasvir + Tenofovir alafenamide
Severity: Minor
Glecaprevir / pibrentasvir and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and BCRP, which can increase absorption of tenofovir alafenamide. Exposure to tenofovir is expected to rise modestly, and the combination is generally used in practice.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glecaprevir/pibrentasvir inhibits intestinal P-gp and BCRP efflux of tenofovir alafenamide.
What to do
No dose adjustment is usually needed. Monitor renal function and tenofovir tolerability, especially in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-gp and BCRP, which can increase absorption of tenofovir alafenamide. Exposure to tenofovir is expected to rise modestly, and the combination is generally used in practice.
How serious is the interaction between Glecaprevir / pibrentasvir and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor renal function and tenofovir tolerability, especially in patients with reduced renal function.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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