Drug interactions
Gliclazide + Nitisinone
Severity: Moderate
Gliclazide and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, a main enzyme for gliclazide clearance, so gliclazide levels may increase. This could heighten hypoglycemia risk.
What this interaction means in plain words
Gliclazide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Nitisinone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2C9-mediated gliclazide metabolism.
What to do
Monitor blood glucose after starting nitisinone and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Gliclazide with Nitisinone?
MediHelp rates the interaction as moderate. Gliclazide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9, a main enzyme for gliclazide clearance, so gliclazide levels may increase. This could heighten hypoglycemia risk.
How serious is the interaction between Gliclazide and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting nitisinone and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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