Drug interactions
Gliclazide + Posaconazole
Severity: Moderate
Gliclazide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azole antifungals inhibit the metabolism of sulfonylureas and can raise gliclazide levels, causing hypoglycemia. Posaconazole is mainly a CYP3A4 inhibitor, so the effect on CYP2C9-metabolized gliclazide is likely smaller than with fluconazole or miconazole.
What this interaction means in plain words
Gliclazide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of hepatic metabolism of gliclazide, mainly CYP2C9 with some CYP2C19 involvement.
What to do
Monitor blood glucose during posaconazole therapy and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Gliclazide with Posaconazole?
MediHelp rates the interaction as moderate. Gliclazide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azole antifungals inhibit the metabolism of sulfonylureas and can raise gliclazide levels, causing hypoglycemia. Posaconazole is mainly a CYP3A4 inhibitor, so the effect on CYP2C9-metabolized gliclazide is likely smaller than with fluconazole or miconazole.
How serious is the interaction between Gliclazide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during posaconazole therapy and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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