Drug interactions
Glimepiride + Hydrochlorothiazide
Severity: Minor
Glimepiride and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of glimepiride. Effect is dose-related and generally modest.
What this interaction means in plain words
Glimepiride and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides reduce insulin secretion and peripheral glucose utilization, partly through potassium depletion.
What to do
Monitor blood glucose after starting or adjusting the thiazide and increase the antidiabetic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Glimepiride and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of glimepiride. Effect is dose-related and generally modest.
How serious is the interaction between Glimepiride and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting the thiazide and increase the antidiabetic dose if needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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