Drug interactions
Glimepiride + Insulin degludec-insulin aspart
Severity: Moderate
Glimepiride and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea gives additive glucose lowering and increases the risk of hypoglycemia, which may be severe. This is most likely when starting the combination or reducing food intake.
What this interaction means in plain words
Glimepiride and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive effect: glimepiride stimulates endogenous insulin secretion while exogenous insulin directly lowers glucose.
What to do
Consider reducing the sulfonylurea or insulin dose when combining and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Glimepiride and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with a sulfonylurea gives additive glucose lowering and increases the risk of hypoglycemia, which may be severe. This is most likely when starting the combination or reducing food intake.
How serious is the interaction between Glimepiride and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfonylurea or insulin dose when combining and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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