Drug interactions
Glimepiride + Levoketoconazole
Severity: Moderate
Glimepiride and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole can raise glimepiride exposure, which may intensify its glucose-lowering effect and lead to hypoglycemia. Levoketoconazole is also used in Cushing's syndrome, where glycemic control may shift as cortisol falls.
What this interaction means in plain words
Glimepiride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated glimepiride metabolism (and possibly CYP3A4) by levoketoconazole.
What to do
Monitor blood glucose closely when starting or stopping levoketoconazole and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Glimepiride with Levoketoconazole?
MediHelp rates the interaction as moderate. Glimepiride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole can raise glimepiride exposure, which may intensify its glucose-lowering effect and lead to hypoglycemia. Levoketoconazole is also used in Cushing's syndrome, where glycemic control may shift as cortisol falls.
How serious is the interaction between Glimepiride and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping levoketoconazole and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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