Drug interactions
Glimepiride + Linagliptin
Severity: Moderate
Glimepiride and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin alone rarely causes hypoglycemia, but with a sulfonylurea the hypoglycemia risk increases. The sulfonylurea is the main driver of the added risk.
What this interaction means in plain words
Glimepiride and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: DPP-4 inhibition increases glucose-dependent insulin secretion alongside sulfonylurea-stimulated release.
What to do
Consider lowering the glimepiride dose when adding linagliptin. Monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Glimepiride with Linagliptin?
MediHelp rates the interaction as moderate. Glimepiride and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin alone rarely causes hypoglycemia, but with a sulfonylurea the hypoglycemia risk increases. The sulfonylurea is the main driver of the added risk.
How serious is the interaction between Glimepiride and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glimepiride dose when adding linagliptin. Monitor blood glucose.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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