Drug interactions
Glimepiride + Lopinavir
Severity: Moderate
Glimepiride and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as lopinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glimepiride. Glycemic control can deteriorate over weeks to months.
What this interaction means in plain words
Glimepiride and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose handling opposes the action of glimepiride.
What to do
Monitor blood glucose and HbA1c after starting lopinavir and increase the glimepiride dose or add other therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Lopinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Glimepiride with Lopinavir?
MediHelp rates the interaction as moderate. Glimepiride and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as lopinavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glimepiride. Glycemic control can deteriorate over weeks to months.
How serious is the interaction between Glimepiride and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting lopinavir and increase the glimepiride dose or add other therapy if control worsens.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
