Drug interactions
Glimepiride + Pegvisomant
Severity: Moderate
Glimepiride and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone receptors, which lowers IGF-1 and removes the diabetogenic effect of growth hormone. In people with diabetes on glimepiride, glucose can fall and hypoglycemia becomes more likely.
What this interaction means in plain words
Glimepiride and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism increases insulin sensitivity, adding to sulfonylurea glucose lowering.
What to do
Monitor blood glucose after starting pegvisomant and reduce glimepiride if glucose falls. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Glimepiride with Pegvisomant?
MediHelp rates the interaction as moderate. Glimepiride and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone receptors, which lowers IGF-1 and removes the diabetogenic effect of growth hormone. In people with diabetes on glimepiride, glucose can fall and hypoglycemia becomes more likely.
How serious is the interaction between Glimepiride and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce glimepiride if glucose falls. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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