Drug interactions
Glimepiride + Trazodone
Severity: Minor
Glimepiride and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants can alter glycemic control in diabetic patients, and trazodone has been reported to have variable effects on blood glucose. The effect on sulfonylurea response is small and inconsistent.
What this interaction means in plain words
Glimepiride and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not well established.
What to do
No dose change is needed routinely; check blood glucose more often when trazodone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Trazodone?
MediHelp rates the interaction as minor. Glimepiride and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants can alter glycemic control in diabetic patients, and trazodone has been reported to have variable effects on blood glucose. The effect on sulfonylurea response is small and inconsistent.
How serious is the interaction between Glimepiride and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely; check blood glucose more often when trazodone is started or stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
