Drug interactions
Glipizide + Indomethacin
Severity: Moderate
Glipizide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as indomethacin may enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. The effect is variable and not seen in every patient.
What this interaction means in plain words
Glipizide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding and prostaglandin-mediated effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping indomethacin and counsel the patient on hypoglycemia symptoms. Reduce the glipizide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Indomethacin?
MediHelp rates the interaction as moderate. Glipizide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as indomethacin may enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. The effect is variable and not seen in every patient.
How serious is the interaction between Glipizide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping indomethacin and counsel the patient on hypoglycemia symptoms. Reduce the glipizide dose if glucose falls.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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