Drug interactions
Glipizide + Linezolid
Severity: Moderate
Glipizide and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid labeling warns of hypoglycemia in diabetic patients taking insulin or oral hypoglycemic agents, so glipizide's effect may be enhanced. Episodes can be significant in patients with irregular eating.
What this interaction means in plain words
Glipizide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
The mechanism is not established; MAO inhibition by linezolid may contribute to enhanced glucose lowering.
What to do
Monitor blood glucose closely during linezolid therapy and lower the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Linezolid?
MediHelp rates the interaction as moderate. Glipizide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid labeling warns of hypoglycemia in diabetic patients taking insulin or oral hypoglycemic agents, so glipizide's effect may be enhanced. Episodes can be significant in patients with irregular eating.
How serious is the interaction between Glipizide and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during linezolid therapy and lower the glipizide dose if hypoglycemia occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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