Drug interactions
Glipizide + Nadolol
Severity: Moderate
Glipizide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers such as nadolol can mask adrenergic warning signs of hypoglycemia, such as tremor and palpitations, and may prolong recovery from low glucose. They may also modestly impair glycemic control.
What this interaction means in plain words
Glipizide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade suppresses the counterregulatory response and the symptoms of hypoglycemia.
What to do
Monitor blood glucose more often and counsel the patient that sweating may be the only preserved warning sign. Consider a cardioselective beta-blocker if one is clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glipizide with Nadolol?
MediHelp rates the interaction as moderate. Glipizide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers such as nadolol can mask adrenergic warning signs of hypoglycemia, such as tremor and palpitations, and may prolong recovery from low glucose. They may also modestly impair glycemic control.
How serious is the interaction between Glipizide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and counsel the patient that sweating may be the only preserved warning sign. Consider a cardioselective beta-blocker if one is clinically appropriate.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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