Drug interactions
Glipizide + Probenecid
Severity: Moderate
Glipizide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may prolong the effect of sulfonylureas such as glipizide and increase the risk of hypoglycemia. The magnitude is variable and generally manageable.
What this interaction means in plain words
Glipizide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Probenecid belongs to Genitourinary.
Why it happens
Probenecid may reduce the renal tubular secretion of glipizide and its metabolites; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping probenecid. Reduce the glipizide dose if low glucose readings occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Probenecid?
MediHelp rates the interaction as moderate. Glipizide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid may prolong the effect of sulfonylureas such as glipizide and increase the risk of hypoglycemia. The magnitude is variable and generally manageable.
How serious is the interaction between Glipizide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping probenecid. Reduce the glipizide dose if low glucose readings occur.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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