Drug interactions
Glipizide + Ritonavir
Severity: Moderate
Glipizide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir has mixed effects on drug-metabolizing enzymes, so glipizide exposure may rise or fall. Protease inhibitors can also cause insulin resistance and hyperglycemia, which can reduce diabetes control independently.
What this interaction means in plain words
Glipizide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir has variable effects on CYP enzymes (inhibition and induction) and protease inhibitors can cause insulin resistance.
What to do
Monitor blood glucose regularly after starting or stopping ritonavir and adjust the glipizide dose to the observed response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Glipizide with Ritonavir?
MediHelp rates the interaction as moderate. Glipizide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir has mixed effects on drug-metabolizing enzymes, so glipizide exposure may rise or fall. Protease inhibitors can also cause insulin resistance and hyperglycemia, which can reduce diabetes control independently.
How serious is the interaction between Glipizide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting or stopping ritonavir and adjust the glipizide dose to the observed response.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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