Drug interactions
Glipizide + Semaglutide
Severity: Moderate
Glipizide and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide used with glipizide increases the risk of hypoglycemia. Semaglutide alone rarely causes hypoglycemia, but the sulfonylurea effect is amplified.
What this interaction means in plain words
Glipizide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: GLP-1 receptor agonism enhances glucose-dependent insulin secretion on top of sulfonylurea-driven insulin release.
What to do
Consider reducing the glipizide dose when starting semaglutide. Monitor blood glucose and educate the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Semaglutide
Frequently asked questions
Can I take Glipizide with Semaglutide?
MediHelp rates the interaction as moderate. Glipizide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide used with glipizide increases the risk of hypoglycemia. Semaglutide alone rarely causes hypoglycemia, but the sulfonylurea effect is amplified.
How serious is the interaction between Glipizide and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when starting semaglutide. Monitor blood glucose and educate the patient on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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