Drug interactions
Glipizide + Sparsentan
Severity: Moderate
Glipizide and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C9, which is a main pathway of glipizide metabolism, and may reduce glipizide exposure. This can lead to reduced glycemic control.
What this interaction means in plain words
Glipizide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Induction of CYP2C9 by sparsentan increases glipizide clearance.
What to do
Monitor blood glucose after starting sparsentan and increase the glipizide dose if control worsens. Reassess if sparsentan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Glipizide with Sparsentan?
MediHelp rates the interaction as moderate. Glipizide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2C9, which is a main pathway of glipizide metabolism, and may reduce glipizide exposure. This can lead to reduced glycemic control.
How serious is the interaction between Glipizide and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting sparsentan and increase the glipizide dose if control worsens. Reassess if sparsentan is stopped.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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