Drug interactions
Glipizide + Sulindac
Severity: Moderate
Glipizide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the hypoglycemic effect of sulfonylureas in some patients. The effect is infrequent but can matter in elderly or renally impaired patients.
What this interaction means in plain words
Glipizide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and prostaglandin-mediated effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when sulindac is started or stopped and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Sulindac?
MediHelp rates the interaction as moderate. Glipizide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the hypoglycemic effect of sulfonylureas in some patients. The effect is infrequent but can matter in elderly or renally impaired patients.
How serious is the interaction between Glipizide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulindac is started or stopped and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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