Drug interactions
Glipizide + Tranylcypromine
Severity: Moderate
Glipizide and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the glucose-lowering action of sulfonylureas, leading to hypoglycemia in some patients.
What this interaction means in plain words
Glipizide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Probable additive glucose lowering; exact mechanism uncertain.
What to do
Check blood glucose more often when the MAO inhibitor is started, changed or stopped. Lower the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Tranylcypromine?
MediHelp rates the interaction as moderate. Glipizide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may potentiate the glucose-lowering action of sulfonylureas, leading to hypoglycemia in some patients.
How serious is the interaction between Glipizide and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when the MAO inhibitor is started, changed or stopped. Lower the glipizide dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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