Drug interactions
Glipizide + Warfarin
Severity: Moderate
Glipizide and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are metabolized by CYP2C9, so the combination may alter warfarin's effect or increase the risk of hypoglycemia from glipizide. Clinically significant changes are uncommon.
What this interaction means in plain words
Glipizide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding may change exposure to either drug.
What to do
Check INR when starting or stopping glipizide and monitor blood glucose for hypoglycemia. Adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Warfarin?
MediHelp rates the interaction as moderate. Glipizide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are metabolized by CYP2C9, so the combination may alter warfarin's effect or increase the risk of hypoglycemia from glipizide. Clinically significant changes are uncommon.
How serious is the interaction between Glipizide and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR when starting or stopping glipizide and monitor blood glucose for hypoglycemia. Adjust doses based on response.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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