Drug interactions
Glipizide-metformin + Leuprolide
Severity: Moderate
Glipizide-metformin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as leuprolide is associated with insulin resistance and worsened glycemic control in men with diabetes. Glucose-lowering requirements may therefore increase during long-term treatment.
What this interaction means in plain words
Glipizide-metformin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Leuprolide belongs to Endocrine.
Why it happens
Testosterone suppression increases fat mass and insulin resistance, which can reduce the effectiveness of glucose-lowering drugs.
What to do
Monitor HbA1c and fasting glucose at regular intervals after starting leuprolide and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Glipizide-metformin with Leuprolide?
MediHelp rates the interaction as moderate. Glipizide-metformin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with GnRH agonists such as leuprolide is associated with insulin resistance and worsened glycemic control in men with diabetes. Glucose-lowering requirements may therefore increase during long-term treatment.
How serious is the interaction between Glipizide-metformin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HbA1c and fasting glucose at regular intervals after starting leuprolide and adjust antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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