Drug interactions
Glipizide-metformin + Medroxyprogesterone
Severity: Minor
Glipizide-metformin and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins, particularly at higher doses, may impair glucose tolerance and reduce the effect of antidiabetic drugs. The effect is usually modest with contraceptive doses.
What this interaction means in plain words
Glipizide-metformin and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Progestins can increase insulin resistance, partially opposing glucose-lowering therapy.
What to do
Monitor glucose control when starting or stopping medroxyprogesterone and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Glipizide-metformin with Medroxyprogesterone?
MediHelp rates the interaction as minor. Glipizide-metformin and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins, particularly at higher doses, may impair glucose tolerance and reduce the effect of antidiabetic drugs. The effect is usually modest with contraceptive doses.
How serious is the interaction between Glipizide-metformin and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when starting or stopping medroxyprogesterone and adjust antidiabetic doses if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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