Drug interactions
Glipizide-metformin + Prochlorperazine
Severity: Minor
Glipizide-metformin and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. The effect is usually small with short-term antiemetic use.
What this interaction means in plain words
Glipizide-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazines may reduce insulin secretion and cause insulin resistance, opposing antidiabetic action.
What to do
Monitor blood glucose if prochlorperazine is used long term or at high doses. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Glipizide-metformin with Prochlorperazine?
MediHelp rates the interaction as minor. Glipizide-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as prochlorperazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. The effect is usually small with short-term antiemetic use.
How serious is the interaction between Glipizide-metformin and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if prochlorperazine is used long term or at high doses. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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