Drug interactions
Glipizide-metformin + Vilazodone
Severity: Minor
Glipizide-metformin and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants may affect glycemic control, with occasional hypoglycemia reported in patients on antidiabetic drugs. Evidence for vilazodone specifically is limited.
What this interaction means in plain words
Glipizide-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Serotonergic effects may alter insulin sensitivity and glucose homeostasis; the mechanism is not well defined.
What to do
Monitor blood glucose after starting or stopping vilazodone. Adjust the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Vilazodone?
MediHelp rates the interaction as minor. Glipizide-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonergic antidepressants may affect glycemic control, with occasional hypoglycemia reported in patients on antidiabetic drugs. Evidence for vilazodone specifically is limited.
How serious is the interaction between Glipizide-metformin and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping vilazodone. Adjust the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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