Drug interactions
Glofitamab + Pirfenidone
Severity: Moderate
Glofitamab and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP450 activity. Pirfenidone, a CYP1A2 substrate, may accumulate during these episodes, increasing the risk of its adverse effects.
What this interaction means in plain words
Glofitamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Pirfenidone belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP1A2 reduces pirfenidone metabolism.
What to do
Monitor for pirfenidone toxicity and liver enzymes during glofitamab initiation and cytokine release syndrome. Reduce or hold pirfenidone if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Pirfenidone?
MediHelp rates the interaction as moderate. Glofitamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release that can transiently suppress CYP450 activity. Pirfenidone, a CYP1A2 substrate, may accumulate during these episodes, increasing the risk of its adverse effects.
How serious is the interaction between Glofitamab and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone toxicity and liver enzymes during glofitamab initiation and cytokine release syndrome. Reduce or hold pirfenidone if adverse effects emerge.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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