Drug interactions
Glofitamab + Quinine
Severity: Moderate
Glofitamab and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP enzymes, possibly raising quinine levels. Because quinine has a narrow therapeutic window, increased exposure may cause toxicity.
What this interaction means in plain words
Glofitamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces quinine clearance.
What to do
Monitor for quinine toxicity such as tinnitus and QT prolongation, particularly during the first cycle and any cytokine release syndrome. Reduce the quinine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Quinine?
MediHelp rates the interaction as moderate. Glofitamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release that can transiently suppress CYP enzymes, possibly raising quinine levels. Because quinine has a narrow therapeutic window, increased exposure may cause toxicity.
How serious is the interaction between Glofitamab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus and QT prolongation, particularly during the first cycle and any cytokine release syndrome. Reduce the quinine dose if toxicity appears.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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