Drug interactions
Glofitamab + Rasagiline
Severity: Minor
Glofitamab and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab triggers cytokine release, which can transiently suppress CYP enzyme activity. Rasagiline is cleared mainly by CYP1A2, so its exposure may rise during cytokine release syndrome, mostly around initiation and step-up dosing.
What this interaction means in plain words
Glofitamab and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glofitamab belongs to Oncology; Rasagiline belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP1A2 may reduce rasagiline clearance.
What to do
Monitor for rasagiline adverse effects such as hypotension, dyskinesia or insomnia during the first cycle and during any cytokine release syndrome. Adjust the rasagiline dose if effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Rasagiline?
MediHelp rates the interaction as minor. Glofitamab and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glofitamab triggers cytokine release, which can transiently suppress CYP enzyme activity. Rasagiline is cleared mainly by CYP1A2, so its exposure may rise during cytokine release syndrome, mostly around initiation and step-up dosing.
How serious is the interaction between Glofitamab and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rasagiline adverse effects such as hypotension, dyskinesia or insomnia during the first cycle and during any cytokine release syndrome. Adjust the rasagiline dose if effects emerge.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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