Drug interactions
Glofitamab + Ropinirole
Severity: Minor
Glofitamab and Ropinirole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Ropinirole exposure may rise, especially around the first doses and during cytokine release syndrome, increasing the risk of dopaminergic adverse effects.
What this interaction means in plain words
Glofitamab and Ropinirole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glofitamab belongs to Oncology; Ropinirole belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes reduces ropinirole clearance.
What to do
Monitor for somnolence, dizziness, nausea and hypotension during the first treatment cycles and during cytokine release syndrome. Lower the ropinirole dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Ropinirole?
MediHelp rates the interaction as minor. Glofitamab and Ropinirole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Ropinirole exposure may rise, especially around the first doses and during cytokine release syndrome, increasing the risk of dopaminergic adverse effects.
How serious is the interaction between Glofitamab and Ropinirole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness, nausea and hypotension during the first treatment cycles and during cytokine release syndrome. Lower the ropinirole dose if needed.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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