Drug interactions
Glucagon + Metoprolol
Severity: Minor
Glucagon and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon exerts positive chronotropic and inotropic effects independent of beta-receptors, so it can counteract beta-blocker effects. This is exploited in beta-blocker overdose, but glucagon given for other reasons may transiently raise pulse and blood pressure in patients on metoprolol.
What this interaction means in plain words
Glucagon and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Metoprolol belongs to Cardiovascular.
Why it happens
Glucagon increases cardiac cAMP through its own receptor, bypassing beta-adrenergic blockade.
What to do
No routine action is needed. Monitor heart rate and blood pressure after glucagon administration in beta-blocked patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrronium Moderate
- Glucagon + Hyoscyamine Moderate
Frequently asked questions
Can I take Glucagon with Metoprolol?
MediHelp rates the interaction as minor. Glucagon and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon exerts positive chronotropic and inotropic effects independent of beta-receptors, so it can counteract beta-blocker effects. This is exploited in beta-blocker overdose, but glucagon given for other reasons may transiently raise pulse and blood pressure in patients on metoprolol.
How serious is the interaction between Glucagon and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor heart rate and blood pressure after glucagon administration in beta-blocked patients.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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