Drug interactions
Glucagon + Nadolol
Severity: Moderate
Glucagon and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon can transiently raise heart rate and blood pressure, and this response may be exaggerated in patients on non-selective beta-blockers such as nadolol because of unopposed vascular effects. Beta-blockers can also blunt the glycemic recovery and mask hypoglycemia symptoms.
What this interaction means in plain words
Glucagon and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucagon belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Glucagon's catecholamine-mediated cardiovascular effects interact with nadolol's beta-blockade, and glucagon effects on glucose may be altered.
What to do
Monitor blood pressure, heart rate and glucose after glucagon administration in nadolol-treated patients. Treat any significant hypertension according to usual practice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glucagon with Nadolol?
MediHelp rates the interaction as moderate. Glucagon and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon can transiently raise heart rate and blood pressure, and this response may be exaggerated in patients on non-selective beta-blockers such as nadolol because of unopposed vascular effects. Beta-blockers can also blunt the glycemic recovery and mask hypoglycemia symptoms.
How serious is the interaction between Glucagon and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and glucose after glucagon administration in nadolol-treated patients. Treat any significant hypertension according to usual practice.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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