Drug interactions
Glucagon + Nebivolol
Severity: Minor
Glucagon and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon increases heart rate and contractility independent of beta receptors, so it can counteract beta-blocker effects and is used in beta-blocker overdose. In patients on therapeutic nebivolol, it may cause transient rises in pulse and blood pressure, and the beta-blocker may not mask hypoglycemia symptoms fully.
What this interaction means in plain words
Glucagon and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Nebivolol belongs to Cardiovascular.
Why it happens
Glucagon acts via glucagon receptors and cAMP, bypassing beta-adrenergic blockade and producing opposing cardiovascular effects.
What to do
Usually no action is needed beyond monitoring pulse and blood pressure after glucagon. The interaction can be used therapeutically in beta-blocker toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Nebivolol?
MediHelp rates the interaction as minor. Glucagon and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon increases heart rate and contractility independent of beta receptors, so it can counteract beta-blocker effects and is used in beta-blocker overdose. In patients on therapeutic nebivolol, it may cause transient rises in pulse and blood pressure, and the beta-blocker may not mask hypoglycemia symptoms fully.
How serious is the interaction between Glucagon and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no action is needed beyond monitoring pulse and blood pressure after glucagon. The interaction can be used therapeutically in beta-blocker toxicity.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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