Drug interactions
Glucagon + Orphenadrin
Severity: Moderate
Glucagon and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic drugs such as orphenadrine slow gastrointestinal motility, and glucagon is used to relax gastrointestinal smooth muscle for diagnostic procedures. Using them together may increase gastrointestinal adverse effects including ileus, constipation and abdominal distension. Clinical significance is usually modest with short-term glucagon use.
What this interaction means in plain words
Glucagon and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucagon belongs to Endocrine; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive inhibition of gastrointestinal motility through anticholinergic activity and glucagon-induced smooth muscle relaxation.
What to do
Monitor for abdominal distension, constipation or reduced bowel sounds when glucagon is given during orphenadrine therapy. Consider holding orphenadrine around procedural glucagon use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Orphenadrin?
MediHelp rates the interaction as moderate. Glucagon and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergic drugs such as orphenadrine slow gastrointestinal motility, and glucagon is used to relax gastrointestinal smooth muscle for diagnostic procedures. Using them together may increase gastrointestinal adverse effects including ileus, constipation and abdominal distension. Clinical significance is usually modest with short-term glucagon use.
How serious is the interaction between Glucagon and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal distension, constipation or reduced bowel sounds when glucagon is given during orphenadrine therapy. Consider holding orphenadrine around procedural glucagon use.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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