Drug interactions
Glucagon + Warfarin
Severity: Minor
Glucagon and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Large cumulative doses of glucagon have been associated with an increased warfarin effect and higher INR. This is not expected with the low doses used for emergency hypoglycemia treatment.
What this interaction means in plain words
Glucagon and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not established; glucagon may increase catabolism of vitamin K-dependent clotting factors.
What to do
No action is needed for routine hypoglycemia doses; check INR if prolonged or high-dose glucagon is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Warfarin?
MediHelp rates the interaction as minor. Glucagon and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Large cumulative doses of glucagon have been associated with an increased warfarin effect and higher INR. This is not expected with the low doses used for emergency hypoglycemia treatment.
How serious is the interaction between Glucagon and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for routine hypoglycemia doses; check INR if prolonged or high-dose glucagon is used.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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