Drug interactions
Glyburide + Linagliptin
Severity: Moderate
Glyburide and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin on its own rarely causes hypoglycemia, but combined with a sulfonylurea the risk of hypoglycemia rises. The sulfonylurea is the main contributor to the added risk.
What this interaction means in plain words
Glyburide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: DPP-4 inhibition increases glucose-dependent insulin secretion alongside sulfonylurea-stimulated insulin release.
What to do
Consider lowering the glyburide dose when adding linagliptin. Monitor blood glucose and educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Glyburide with Linagliptin?
MediHelp rates the interaction as moderate. Glyburide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin on its own rarely causes hypoglycemia, but combined with a sulfonylurea the risk of hypoglycemia rises. The sulfonylurea is the main contributor to the added risk.
How serious is the interaction between Glyburide and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when adding linagliptin. Monitor blood glucose and educate the patient about hypoglycemia.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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