Drug interactions
Glyburide + Lopinavir
Severity: Moderate
Glyburide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as lopinavir/ritonavir are associated with insulin resistance and hyperglycemia. This can reduce the effectiveness of glyburide and worsen glycemic control. Ritonavir also affects drug metabolism, so glyburide exposure may change.
What this interaction means in plain words
Glyburide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance opposes the glucose-lowering effect of glyburide.
What to do
Monitor blood glucose regularly after starting or stopping lopinavir. Adjust the glyburide dose or add other agents as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Glyburide with Lopinavir?
MediHelp rates the interaction as moderate. Glyburide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as lopinavir/ritonavir are associated with insulin resistance and hyperglycemia. This can reduce the effectiveness of glyburide and worsen glycemic control. Ritonavir also affects drug metabolism, so glyburide exposure may change.
How serious is the interaction between Glyburide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting or stopping lopinavir. Adjust the glyburide dose or add other agents as needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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