Drug interactions
Glyburide + Metolazone
Severity: Moderate
Glyburide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone can raise blood glucose and reduce the effectiveness of glyburide. Loss of glycemic control may emerge after the diuretic is started or its dose increased.
What this interaction means in plain words
Glyburide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Thiazide-like diuretics impair insulin release and insulin sensitivity, partly via hypokalemia, opposing the sulfonylurea effect.
What to do
Monitor blood glucose and potassium when metolazone is started or adjusted. Adjust the glyburide dose or add therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Metolazone?
MediHelp rates the interaction as moderate. Glyburide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone can raise blood glucose and reduce the effectiveness of glyburide. Loss of glycemic control may emerge after the diuretic is started or its dose increased.
How serious is the interaction between Glyburide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when metolazone is started or adjusted. Adjust the glyburide dose or add therapy if control worsens.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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