Drug interactions
Glyburide + Miglitol
Severity: Minor
Glyburide and Miglitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol has been reported to reduce glyburide exposure in pharmacokinetic studies, which could slightly weaken its glucose-lowering effect. Both drugs lower glucose, so the combination is used in practice and the net result is usually acceptable.
What this interaction means in plain words
Glyburide and Miglitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Miglitol may reduce the absorption of glyburide; the exact mechanism is not well established.
What to do
Monitor glucose control when the combination is started. Adjust the glyburide dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Glyburide with Miglitol?
MediHelp rates the interaction as minor. Glyburide and Miglitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miglitol has been reported to reduce glyburide exposure in pharmacokinetic studies, which could slightly weaken its glucose-lowering effect. Both drugs lower glucose, so the combination is used in practice and the net result is usually acceptable.
How serious is the interaction between Glyburide and Miglitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when the combination is started. Adjust the glyburide dose if control is inadequate.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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