Drug interactions
Glyburide + Nitazoxanide
Severity: Minor
Glyburide and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide is highly protein bound, so it could theoretically displace glyburide from plasma proteins. No clinically meaningful interaction has been well documented, and nitazoxanide is used only for short courses.
What this interaction means in plain words
Glyburide and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding between tizoxanide and glyburide.
What to do
No routine change is needed; advise the patient to report hypoglycemia symptoms during the nitazoxanide course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Glyburide with Nitazoxanide?
MediHelp rates the interaction as minor. Glyburide and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide is highly protein bound, so it could theoretically displace glyburide from plasma proteins. No clinically meaningful interaction has been well documented, and nitazoxanide is used only for short courses.
How serious is the interaction between Glyburide and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise the patient to report hypoglycemia symptoms during the nitazoxanide course.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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