Drug interactions
Glyburide + Tenapanor
Severity: Minor
Glyburide and Tenapanor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor inhibits intestinal OATP2B1, and glyburide is an OATP2B1 substrate, so glyburide absorption may fall. This could modestly reduce glycemic control.
What this interaction means in plain words
Glyburide and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Tenapanor inhibits intestinal OATP2B1 uptake, reducing glyburide absorption.
What to do
Monitor blood glucose after starting tenapanor and adjust the glyburide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide and Tenapanor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Enalapril + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
Frequently asked questions
Can I take Glyburide with Tenapanor?
MediHelp rates the interaction as minor. Glyburide and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenapanor inhibits intestinal OATP2B1, and glyburide is an OATP2B1 substrate, so glyburide absorption may fall. This could modestly reduce glycemic control.
How serious is the interaction between Glyburide and Tenapanor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting tenapanor and adjust the glyburide dose if control worsens.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
