Drug interactions
Glyburide-metformin + Lanreotide
Severity: Moderate
Glyburide-metformin and Lanreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can change glucose control in diabetic patients. Either hyperglycemia or hypoglycemia can occur, so antidiabetic doses may need adjustment.
What this interaction means in plain words
Glyburide-metformin and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Lanreotide belongs to Endocrine.
Why it happens
Somatostatin analog inhibition of insulin and glucagon secretion alters glucose homeostasis, opposing or altering the effects of antidiabetic drugs.
What to do
Monitor blood glucose when lanreotide is started, changed or stopped, and adjust glyburide-metformin accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Glyburide-metformin with Lanreotide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can change glucose control in diabetic patients. Either hyperglycemia or hypoglycemia can occur, so antidiabetic doses may need adjustment.
How serious is the interaction between Glyburide-metformin and Lanreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lanreotide is started, changed or stopped, and adjust glyburide-metformin accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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