Drug interactions
Glyburide-metformin + Leuprolide
Severity: Moderate
Glyburide-metformin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide-induced androgen deprivation is associated with insulin resistance and impaired glucose tolerance. This can worsen glycemic control in patients taking antidiabetic drugs.
What this interaction means in plain words
Glyburide-metformin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Leuprolide belongs to Endocrine.
Why it happens
GnRH agonist-induced hypogonadism increases insulin resistance and fat mass, opposing the effect of antidiabetic therapy.
What to do
Monitor fasting glucose and HbA1c after starting leuprolide. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Glyburide-metformin with Leuprolide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide-induced androgen deprivation is associated with insulin resistance and impaired glucose tolerance. This can worsen glycemic control in patients taking antidiabetic drugs.
How serious is the interaction between Glyburide-metformin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting leuprolide. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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