Drug interactions
Glyburide-metformin + Liothyronine
Severity: Moderate
Glyburide-metformin and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can increase glucose production and raise metabolic demand, which may worsen glycemic control in diabetic patients. Antidiabetic doses may need to be increased when thyroid replacement is started or adjusted.
What this interaction means in plain words
Glyburide-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Liothyronine belongs to Endocrine.
Why it happens
Thyroid hormones increase hepatic glucose output and gut glucose absorption, opposing the effects of antidiabetic drugs.
What to do
Monitor blood glucose when starting or changing liothyronine and adjust antidiabetic doses; watch for hypoglycemia if thyroid dosing is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Glyburide-metformin with Liothyronine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can increase glucose production and raise metabolic demand, which may worsen glycemic control in diabetic patients. Antidiabetic doses may need to be increased when thyroid replacement is started or adjusted.
How serious is the interaction between Glyburide-metformin and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing liothyronine and adjust antidiabetic doses; watch for hypoglycemia if thyroid dosing is reduced.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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