Drug interactions
Glyburide-metformin + Nitisinone
Severity: Moderate
Glyburide-metformin and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, which contributes to glyburide metabolism, so glyburide exposure may rise. This can increase the risk of hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Nitisinone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2C9-mediated glyburide metabolism raises glyburide plasma concentrations.
What to do
Monitor blood glucose closely when nitisinone is started and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Glyburide-metformin with Nitisinone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9, which contributes to glyburide metabolism, so glyburide exposure may rise. This can increase the risk of hypoglycemia.
How serious is the interaction between Glyburide-metformin and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when nitisinone is started and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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