Drug interactions
Glyburide-metformin + Pentamidine
Severity: Moderate
Glyburide-metformin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine is toxic to pancreatic beta cells and can cause both hypoglycemia and later hyperglycemia or diabetes. This makes glucose control unpredictable with glyburide-metformin, and hypoglycemia may be amplified.
What this interaction means in plain words
Glyburide-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine-induced beta-cell injury causes insulin release followed by insulin deficiency, altering glycemic response.
What to do
Monitor blood glucose closely during and after pentamidine and adjust or hold the sulfonylurea as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Pentamidine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine is toxic to pancreatic beta cells and can cause both hypoglycemia and later hyperglycemia or diabetes. This makes glucose control unpredictable with glyburide-metformin, and hypoglycemia may be amplified.
How serious is the interaction between Glyburide-metformin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after pentamidine and adjust or hold the sulfonylurea as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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