Drug interactions
Glyburide-metformin + Sodium zirconium cyclosilicate
Severity: Minor
Glyburide-metformin and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can transiently raise gastric pH, which may alter the absorption of drugs whose solubility depends on pH. Glyburide is one such drug, so its absorption could change.
What this interaction means in plain words
Glyburide-metformin and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increase in gastric pH may alter the dissolution and absorption of pH-sensitive oral drugs such as glyburide.
What to do
Give glyburide-metformin at least 2 hours before or after sodium zirconium cyclosilicate and monitor glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Sodium zirconium cyclosilicate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Glyburide-metformin with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Glyburide-metformin and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can transiently raise gastric pH, which may alter the absorption of drugs whose solubility depends on pH. Glyburide is one such drug, so its absorption could change.
How serious is the interaction between Glyburide-metformin and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glyburide-metformin at least 2 hours before or after sodium zirconium cyclosilicate and monitor glucose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
