Drug interactions
Glyburide-metformin + Vilazodone
Severity: Minor
Glyburide-metformin and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants can alter glucose homeostasis, and hypoglycemia has been reported when they are combined with antidiabetic agents, especially sulfonylureas. The effect is variable and usually modest.
What this interaction means in plain words
Glyburide-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Serotonergic modulation of insulin sensitivity and secretion may add to the glucose-lowering effect; mechanism not firmly established.
What to do
Monitor blood glucose when starting or changing vilazodone and reduce the glyburide dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Vilazodone?
MediHelp rates the interaction as minor. Glyburide-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonergic antidepressants can alter glucose homeostasis, and hypoglycemia has been reported when they are combined with antidiabetic agents, especially sulfonylureas. The effect is variable and usually modest.
How serious is the interaction between Glyburide-metformin and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing vilazodone and reduce the glyburide dose if hypoglycemia develops.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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