Drug interactions
Glycopyrrolate + Tiotropium-olodaterol
Severity: Moderate
Glycopyrrolate and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate adds systemic antimuscarinic effects to inhaled tiotropium, which can increase dry mouth, constipation, urinary retention, tachycardia and blurred vision. The risk is greater in older patients and those with glaucoma or prostatic hyperplasia.
What this interaction means in plain words
Glycopyrrolate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid routine combination of anticholinergics and monitor for urinary retention, constipation and eye symptoms. Consider whether both agents are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Glycopyrrolate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrrolate adds systemic antimuscarinic effects to inhaled tiotropium, which can increase dry mouth, constipation, urinary retention, tachycardia and blurred vision. The risk is greater in older patients and those with glaucoma or prostatic hyperplasia.
How serious is the interaction between Glycopyrrolate and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of anticholinergics and monitor for urinary retention, constipation and eye symptoms. Consider whether both agents are needed.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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